This page gives patients, carers and parents’ information about using ENTONOX® as pain relief.

What is ENTONOX®?

It is an odourless, colourless gas that has been used for reliable pain relief for over 150 years. It is often used to treat pain during childbirth. It is also used by the Ambulance Service and in hospitals for a variety of short procedures.

How is ENTONOX® given?

It is managed by you, by breathing through a mouthpiece or mask and supervised by a trained healthcare professional. ENTONOX® is safe to use for children and adults, as long as they can follow simple instructions.

How long does it take ENTONOX® to work?

ENTONOX® will begin to take effect immediately when you start to inhale the gas. When stopped, the effects of the gas will wear off quickly.

What are the risks?

There is minimal risk involved with the administration of ENTONOX®. One concern is that the gas may become trapped in the body. This is only a problem if you have certain medical conditions. Please inform the healthcare professional of any medical conditions that you have and of any recent surgery.

Is it safe to use ENTONOX® while pregnant?

Yes, it is. However, it is best to avoid using it during the first and second trimesters of pregnancy. Your healthcare professional will answer any questions you may have.

Are there any side-effects of using ENTONOX®?

You may get tingling lips and fingertips, feel a little sick or dizzy and it can also give you the ‘giggles’. These effects disappear as the gas eases the pain. It is not recommended to use ENTONOX® for long periods as it can cause blood disorders and possible addiction. You cannot overdose on this medication.

How soon can I drive after using ENTONOX®?

You should not drive a car or operate any machinery for at least 30 minutes after having ENTONOX®.

Taking other medication with ENTONOX®

Please let the healthcare professional know if you are currently taking any other medication. It is unsafe to use ENTONOX® with some medicines.

Further information

Printable version of this page

ENTONOX (gas and air) GHPI1070_04_24 Department: Pain Service Review due: April 2027 PDF, 298.9 KB, 3 pages
Reference number GHPI1070_04_24
Department Pain Service
Review due April 2027