Myelin Associated Glycoprotein Antibodies (MAG)

Department of Immunology

Notes

• Myelin Associated Glycoprotein (MAG) autoantibodies are frequently associated with peripheral neuropathy and frequently occur with IgM paraproteinaemia.
• MAG autoantibodies, contribute directly to the pathogenesis of peripheral neuropathies. Patients with anti-MAG antibody titres may respond favourably to therapeutic intervention.
• Testing for the presence of these autoantibodies is useful for diagnosis as well as monitoring of therapy.
• Test performed by Oxford University Hospitals NHS Foundation Trust.

Sample Requirements

Clotted blood. (No patient preparation or special handling required)

Adult

5ml Gold-top SST tube or 3.5ml Rust-top gel tube (Trust users only)

Paediatric

1ml serum Sample

Time limit for add-on

3 days

Turnaround Times

28 days

Reference Range

Negative <1000 BTU (Bulhmann Titre Units)

Low Positive 1000-3000 BTU

High Positive > 70000 BTU